MTHFR Polymorphisms and Leukoencephalopathy Risk in CNS Lymphoma Patients

Dr. Philipp Karschnia discusses the association between MTHFR polymorphisms and leukoencephalopathy risk in CNS lymphoma patients treated with methotrexate-based regimens. The podcast explores the relationship between MTHFR polymorphisms and increased risk of leukoencephalopathy in patients exposed to methotrexate. The study also discusses the impact of MTHFR polymorphism on mucositis and overall survival in CNS lymphoma patients. Limitations of the study are highlighted and the need for further verification and cognitive testing in clinical trials is emphasized.