NEJM This Week NEJM This Week — August 21, 2025
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Aug 20, 2025 Delve into the latest breakthroughs in cancer treatments, particularly lung cancer and high-risk skin cancers. Discover the transformative potential of AI in medical education, balancing benefits with risks. Explore effective strategies for enhancing critical thinking among clinical supervisors. The discussion also tackles pressing health policy issues, including vaccine recommendations, preventive services, and the regulation of private equity in healthcare, highlighting the significance of equitable access to care.
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Neoadjuvant Immunotherapy Improves Survival
- Neoadjuvant nivolumab plus chemotherapy improved overall survival and pathological complete response in resectable NSCLC.
- The trial shows adaptive designs and international collaboration can change treatment standards.
Neurokinin Drug Eases Hot Flashes
- Elinzanatant significantly reduced endocrine-therapy–related vasomotor symptoms compared with placebo in women with HR-positive breast cancer.
- Tolerability (somnolence, fatigue, diarrhea) will determine real-world adoption and patient-centered use.
Inhaled GM-CSF Advances APAP Care
- Daily inhaled molgramostim increased lung diffusion capacity versus placebo in autoimmune pulmonary alveolar proteinosis.
- The trial positions inhaled GM-CSF as a likely new standard, replacing whole-lung lavage for many patients.