Serine-129 Phosphorylation of α-Synuclein

The podcast delves into the pivotal role of alpha-synuclein in Parkinson's disease pathology, discussing genetic connections, protein accumulation in brain cells, and its normal abundance in the brain. It explores the impact of phosphorylation on alpha-synuclein's role in synapse function and neurotransmission inhibition, shedding light on the intricate protein-protein interactions vital for synaptic regulation. The discussion also highlights the dual role of phosphorylation in alpha-synuclein protein and its implications in neurodegenerative disorders like Parkinson's disease.