Raising Health
Unleashing CAR T with Carl June
May 7, 2024
Pioneering immunologist, Carl June, discusses his work on CAR T cell therapy, including its origins in HIV treatment, effectiveness in treating B cell malignancies, challenges with cytokine storms, and future prospects for cancer treatment advancements.
27:11
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Quick takeaways
- CAR T cell therapy shows efficacy in treating various cancers through CD28 activation.
- Future innovations in CAR T therapy aim to enhance potency in treating solid tumors through metabolic rewiring and enhanced targeting.
Deep dives
Pioneering CAR T Cell Therapy in Cancer Treatment
Dr. Carl June, a luminary in medicine, pioneered CAR T cell treatment. Beginning his journey with an immunology focus due to familial autoimmune diseases, he delved into T cell immunology during his naval service. Linking immunology with HIV studies, he embarked on developing CAR T cell therapy. Through CD28 activation, CAR T cells showed efficacy against cancers, leading to prolonged responses and potential for treating a range of cancers.
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