Author Tom Ireland joins the show to discuss the fascinating world of bacteriophages, also known as phages. Ben Chan tells the story of putting phages to use in a high-stakes case. Can phages help us fight antibiotic-resistant infections?
Phages, or bacteria phages, are viruses that kill bacteria and are now being used to treat infections that cannot be cured with antibiotics.
Phage therapy offers an alternative to antibiotics in the fight against antibiotic-resistant bacteria, with the potential to revolutionize infection management and provide hope in the face of antibiotic resistance.
Deep dives
Phages: The Good Viruses
Phages, or bacteria phages, are viruses that kill bacteria and are now being used to treat infections that cannot be cured with antibiotics. The World Economic Forum named phage therapy as one of the top 10 emerging technologies for 2023. Phages have a unique structure with a 20-sided head that contains the DNA and a long tail that acts as a molecular syringe to inject genes into bacteria. Phages have been used in medicine since the 20s and 30s but lost popularity with the rise of antibiotics. However, with the growing issue of antibiotic resistance, phage therapy is gaining attention as a potential solution.
The Maverick Scientist: Felix D'Arrel
Felix D'Arrel, a self-taught and unconventional scientist, made groundbreaking discoveries about phages in the 1910s. He observed that phages could kill bacteria efficiently, replicate within them, and potentially be part of our immune system. Despite facing opposition from established microbiologists, D'Arrel successfully used phages to treat dysentery and other bacterial infections. However, the inconsistent results and the advent of antibiotics led to a decline in phage therapy's popularity.
Phage Therapy and Antibiotic Resistance
Phage therapy offers an alternative to antibiotics in the fight against antibiotic-resistant bacteria. While logistical and regulatory challenges exist, phages have evolved over billions of years to effectively kill bacteria. Phage therapy has been used successfully to treat infections that are resistant to every known antibiotic. Clinical trials are ongoing to further establish the safety and efficacy of phage therapy, which could potentially become a more widely available treatment option in the future.
The Future of Phage Therapy
Phage therapy is slowly gaining traction in US medicine, with clinical trials and compassionate use cases being conducted. If these trials demonstrate safety and efficacy, phage therapy could become a more prominent treatment option, potentially impacting thousands of patients annually. However, challenges lie in standardizing and industrializing phage therapy to make it more accessible and cost-effective worldwide. Despite these challenges, phage therapy has the potential to revolutionize infection management and provide hope in the face of antibiotic resistance.
Can bacteriophages help us in the fight against antibiotic-resistant infections? Author Tom Ireland joins the show to discuss the fascinating world of bacteriophages, also known as phages – viruses that attack bacteria.. Then, Ben Chan, a researcher with a fridge full of phages, tells the story of what it was like putting them to use in a high-stakes case.