Science Friday
AI Is Coming Up With Brand New Molecules, Fueling Drug Discovery
Jan 27, 2025
In this engaging discussion, Nobel laureate David Baker leads groundbreaking protein design research at the University of Washington, while César de la Fuente, a bioengineer from the University of Pennsylvania, focuses on AI-driven antibiotics. They delve into the fascinating realm of creating proteins to counter snake venoms and resurrecting genetic data from extinct species to discover new antibiotics. The conversation highlights how AI is revolutionizing drug discovery, presenting a blend of cutting-edge technology and vital medical advancements.
19:00
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Quick takeaways
- Artificial intelligence is revolutionizing drug discovery by enabling the creation of novel proteins specifically designed to combat snake venom threats.
- AI is unlocking the potential of extinct species' genomes to discover natural antibiotics, paving the way for innovative treatments against modern pathogens.
Deep dives
AI-Designed Proteins Combatting Toxins
Artificial intelligence is reshaping the field of protein design by creating new proteins that can neutralize threats such as snake venom. Researchers have developed proteins specifically engineered to bind to venom toxins, allowing them to act like keys fitting into locks. This innovative approach utilizes generative AI methods to create unique protein structures that were previously impossible, expediting the development of effective antivenoms. The process allows scientists to explore thousands of protein designs rapidly, selecting the most promising candidates to test for their ability to inhibit venom's lethal effects.
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