Pondering ALS with Kevin Talbot

Amyotrophic lateral sclerosis (ALS) is the most common type of motoneuron disease and is characterized by progressive weakness and wasting of muscles. Most people with ALS will die within 3 years of the onset of symptoms. Professor Kevin Talbot of Oxford University has devoted his career to advancing an understanding of what goes wrong in ALS with the goal of discovering how it might be prevented and treated. Here I talk with Dr. Talbot about ALS including its epidemiology, genetic and environmental risk factors, cellular and molecular neurobiology, and emerging treatments.

Links:

Review articles:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768794/pdf/41573_2022_Article_612.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047135/pdf/fncel-15-653688.pdf

Clinical Trials: https://clinicaltrials.gov/ct2/results?cond=als&term=&cntry=&state=&city=&dist=

Lecture on ALS: https://www.youtube.com/watch?v=r-Ys6Obd814