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Metastatic cancer can be categorized as cancer of origin to be determined (TBD), which differs from carcinoma of unknown primary. This episode emphasizes the necessity of identifying the source of the cancer and determining its stage to tailor appropriate patient care. A specific example highlighted involves a patient with a significant history of tobacco use who presented with a lung mass and subsequent symptoms. The practitioners note the importance of gathering comprehensive clinical data through consultations and biopsies to adequately address such cases.