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Neurology® Podcast

The Brain’s Action-Mode Network

Jan 30, 2025
Dr. Nico Dosenbach, a neurology professor at Washington University, dives into the intricacies of the brain's action mode network and its relationship with other critical networks. He discusses how resting state functional connectivity informs our understanding of neurological disorders. Dosenbach highlights the evolutionary roles of these networks, emphasizing their significance in goal-directed behavior. The conversation also touches on innovative neuromodulation techniques that may enhance motivation and cognitive function, potentially transforming treatment for patients.
19:04

Episode guests

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Quick takeaways

  • The action mode network plays a vital role in goal-directed actions, highlighting its connection to evolutionary brain development and the default mode network.
  • Neuromodulation techniques show promise in targeting the action mode network for treating neurological disorders like Tourette's syndrome and enhancing cognitive capabilities.

Deep dives

Understanding Resting State Functional Connectivity

Resting state functional connectivity is a method used to measure brain networks by observing spontaneous fluctuations in brain activity while a person is at rest. This approach employs an MRI scanner to track blood oxygenation levels without requiring specific tasks from participants, allowing for a more natural representation of brain activity. Researchers have identified approximately 15 to 20 core functional networks within the brain that are present in all individuals, suggesting their foundational role in neurological and psychiatric health. Disruptions in these networks can lead to various disorders, highlighting their significance in understanding brain functionality.

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