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Hypothyroidism, even in subclinical cases, can increase the risk of developing gallstones. Treatment with thyroid hormones can often resolve these stones. When the thyroid is sluggish, the production of bile salts decreases, leading to a higher likelihood of gallstone formation. Diminished metabolism of cholesterol due to low thyroid hormone levels also contributes to gallstone development. Additionally, hypothyroidism can cause constriction in the bile ducts and gallbladder, resulting in stone formation. Overall, having adequate thyroid hormone levels is crucial in preventing and managing gallbladder problems.