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The Wellness Mama Podcast

GLPs: Myths, Microdosing, Studies and Cautions with McCall McPherson

Mar 31, 2025
34:01

Episode Highlights with McCall McPherson

  • How GLPs were developed and how they became popular for weight loss
  • What GLPs actually are and how they work 
  • The inflammatory pieces related to GLP use and her theory that they may reduce inflammation
  • Inflammation is a common factor in chronic disease but tough to pinpoint and affect, though easy to test
  • She measures HS-CRP on labs to check inflammation 
  • How she is seeing a consistent reduction in autoimmune antibodies with GLPs
  • What to know about muscle loss with GLPs and how to maintain muscle mass if you take them: eat enough protein and strength-building activity 
  • Heart disease kills more people than all cancers combined 
  • A couple of important studies looking at cardiovascular death risk for diabetics on GLPs - 51% risk reduction with GLP use
  • The select trial in non-diabetics found a 21% reduction in heart attack and stroke risk with GLPs
  • How being undernourished and underhydrated can impact metrics like HRV and resting heart rate if people don’t drink enough water on this
  • The real data about thyroid risk and why this is really important to understand 
  • Dosing is so important and overdosing is responsible for the majority of issues

Resources Mentioned

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