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Immune
Immune 67: Can T cells live forever?
May 3, 2023
Podcast discusses the longevity and division capabilities of T cells in mice over 10 years and 51 immunizations. Topics include memory T cell responses, telomere activity, cell transfers in cancer, and advancements in cell research. Conversations also cover hypogammaglobulinemia, ME-CFS, wound healing benefits, and open-access papers on Lupus, virology, and neuroton in immune responses.
01:15:32
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Quick takeaways
- T cells can undergo extended division cycles and maintain functionality, challenging division limits.
- Rest periods between antigen exposure impact T cell longevity; longer intervals crucial for sustained survival.
Deep dives
Cell Division and Longevity of T Cells
T cells have the remarkable ability to undergo numerous cell divisions and still maintain longevity, challenging the conventional understanding of cellular division limits. Experiments revealed that T cells remained viable and functional even after 51 stimulations over 10 years, showing no signs of transformation or loss of growth control. This unique capacity of T cells to proliferate repeatedly while retaining functionality sheds light on the biology of aging and the exceptional properties of T cell memory.
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