Low Carb MD Podcast Tirzepatide, Ketones, and the Sardine Fast | Dr. Annette Bosworth - #458
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Sep 7, 2026 
Dr. Annette Bosworth, a physician and bestselling author focused on metabolic health, explores tirzepatide, ketosis, and fasting. They discuss why GLP-1 medications may stop working, using low doses alongside ketogenic habits, and the role of sardine fasting in quieting food noise. Stress, sleep, mold exposure, behavioral change, and practical metabolic resets also take center stage.
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How A Group Class Changed Ketogenic Care
- Annette Bosworth replaced repetitive one-on-one teaching with a three-week ketogenic class for 200 students.
- Students reported learning more in three weeks than from doctors throughout their lives, while small groups reinforced behavior change.
Testing Tirzepatide In Ketogenic Patients
- Annette Bosworth is studying whether tiny tirzepatide doses can support patients already practicing therapeutic ketosis.
- Her clinician-led data collection remains exploratory, but it tests minimum effective dosing in a population lacking clear guidance.
Tiny Tirzepatide Doses Surprised Everyone
- Starting at approximately 0.6 milligrams weekly, Annette Bosworth expected little effect but saw about 95% avoid dose increases.
- Patients who accidentally overdosed described nearly complete appetite suppression for a week.