Explore the history and impact of psychiatric drugs, including antidepressants and anti-anxiety medications. Learn about the accidental discoveries that led to the creation of these drugs. Discover the connection between lithium and Seven Up and its effectiveness in treating bipolar disorder. Delve into the development and marketing of Caledimite, sodium flap roort, and valproic acid for bipolar disorder. Uncover the concept of 'mother's little helper' and the development of tranquilizers as a safer alternative. Reflect on the importance of mental health in a chaotic world and the need to prioritize global problems.
Psychotropic drugs primarily impact the body and not just the brain, highlighting the interconnectedness of the body in mental functions.
Antihistamines, initially created for allergies, have been repurposed to address mental problems and reduce anxiety.
Deep dives
The Historical Origins of Psychotropic Drugs
Psychotropic drugs, also known as drugs that treat nervous problems, have a long history that dates back to ancient civilizations. In the 1950s, the idea that these drugs act on the brain gained traction, leading to the development of drugs like chlorpromazine, which became the basis for antipsychotics and antidepressants. However, it was discovered that these drugs primarily affect the body rather than just the brain. For example, selective serotonin reuptake inhibitors like Prozac primarily impact serotonin in the body, with only a small amount affecting the brain. This shows that the effects of psychotropic drugs on mental functions can occur through their interactions with the rest of the body. The understanding of psychotropic drugs evolved over time, with advancements in knowledge about their mechanisms of action and potential uses.
The Role of Antihistamines in Psychotropic Drugs
During the early 20th century, the focus of pharmaceutical research shifted towards creating antihistamines. Several antipsychotic and antidepressant drugs later emerged from these developments. It was discovered that antipsychotic drugs like chlorpromazine and antidepressants like Prozac are derived from antihistamines. Antihistamines, which are commonly used to treat allergies, were found to have a notable impact on mental problems as well. For instance, antihistamines with selective serotonin reuptake inhibiting properties can help reduce anxiety. These drugs, available over the counter, can make people less anxious. However, when physicians prescribe similar drugs with similar properties, patients may continue taking them even if they experience adverse effects. Additionally, drugs used to treat other conditions, such as nausea and vomiting, have been repurposed to address major mental illnesses.
The Influence of Stone and Experiments Gone Wrong
The history of psychotropic drugs also involves unique discoveries and accidental breakthroughs. For example, the origin of lithium, a drug used to treat bipolar disorder, can be traced back to certain types of stones, which contain lithium ions. Lithium has been instrumental in managing severe mood disorders, although it is less profitable for pharmaceutical companies due to its low cost. Furthermore, the rise of benzodiazepines like Librium and Valium in the mid-20th century brought significant changes in mental healthcare. These minor tranquilizers, known as 'Mother's Little Helper', gained immense popularity, but their addictive nature became evident after about 20 years. While providing relief for some, these drugs posed risks and raised concerns about overprescription. The future of psychotropic drugs may involve revisiting drugs like LSD, magic mushrooms, and ketamine, which have shown potential for treating various mental health conditions.
The Need for a Holistic Approach and Redefining Mental Health
As the pharmaceutical industry has heavily marketed mental health drugs, it has led to the perception that individuals are continually mentally ill and reliant on medication. However, there is a growing need to shift focus towards a more holistic approach that acknowledges the complexities of mental health issues beyond just the brain. Understanding the interconnectedness of the body and the role of things like relaxation techniques, exercise, and overall well-being is crucial. While some psychotropic drugs have their place and can be helpful, it is essential to recognize that not everyone requires medication or has a mental health disorder. Redefining mental health involves recognizing and addressing the external factors causing anxiety and distress in society, rather than solely relying on drugs to mitigate these issues.
Development and Marketing of Caledimite; Sodium Flap Roort: From Artificial Butter to Medical Treatment; Valproic Acid: Effects on Bipolar Disorder and Pregnant Women
*WARNING this episode includes adult themes and conversations about mental health and drug use.*
In 2020, the UK government revealed that 17% of the adult population of Britain were prescribed medication for their mental health. But when were these drugs invented? How were they tested? And how have they become, in some cases, ‘mother’s little helper’?
From antidepressants and anti-anxiety medications to stimulants and mood stabilisers - Dr David Healy takes us on a journey through the development and use of psychiatric - or psychotropic - medication, and how this development has in turn affected our diagnoses.
David is a psychiatrist and psychopharmacologist, and is a professor of Psychiatry at McMaster University in Canada.
Produced by Charlotte Long and Sophie Gee. Mixed by Aidan Lonergan.
Betwixt the Sheets: The History of Sex, Scandal & Society. A podcast by History Hit.
This episode includes music by Epidemic Sound and archive clips from Zoloft commercial 2001.
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