Bloody Minded Episode 40 - On The Wards: The Antibodies of Wrath | IVIG and Rituximab Reactions
Apr 1, 2025
In this enlightening discussion, consultant haematologist Alison Chandler shares her expertise on infusion reactions related to IVIG and Rituximab. She demystifies these antibody treatments, explaining their origins and how they're used in various medical scenarios. The conversation dives into acute and delayed reactions during IVIG administration, as well as safety protocols and the amusing complexities of antibody naming. With humor woven throughout, Alison makes these intricate topics accessible and engaging for both newbies and seasoned pros in healthcare.
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What Is IVIG?
- IVIG stands for intravenous immunoglobulin, containing pooled IgG antibodies from many donors.
- It only contains IgG subclasses due to safety and effectiveness considerations.
IVIG Sourcing and Regulation
- IVIG is sourced from purified plasma of many blood donors, making it precious and expensive.
- Usage is regulated by special authorities like Australia's National Blood Authority to ensure appropriate use.
Why Use IVIG?
- IVIG is used mainly for two reasons: to replace deficient antibodies and for immunomodulation in autoimmune diseases.
- Most indications fall under these categories, including hematological and neurological disorders.