227. GLP Q&A: Can You Lose Fat and Keep Muscle on GLP agonists?

Most people using GLP agonists are doing it wrong. Semaglutide? Tirzepatide? They’re not magic pills, they’re misunderstood tools. In this episode, I answer your most common questions and break down what these drugs actually do inside the body.

We get into the real science: how GLPs suppress appetite, slow digestion, improve insulin sensitivity, and change energy balance. I explain the difference between GLP‑1, dual agonists like tirzepatide (GLP + GIP), and next-gen options like retatrutide (GLP + GIP + glucagon).

You’ll learn why fat loss happens, why muscle loss is a major risk, and how to train, eat, and supplement so you stay jacked, not soft. We cover the rebound effect when you stop, what stacks are worth considering, and how to avoid wrecking your gut or your gains in the process.

If you're serious about fat loss, muscle retention, and metabolic health, this is mandatory listening. These compounds can change your trajectory. Or wreck it. The difference is your discipline.

What's Discussed:

(00:01) Are GLP Drugs Just Fancy Appetite Suppressants? (02:57) The Real Reason You're Losing Muscle on Semaglutide (05:23) What Happens When You Come Off? The Rebound Most Miss (06:59) Using GLPs as an Athlete? Here's What Can Go Sideways (13:06) How to Actually Maximize GLPs Without Wrecking Your Gains

Thank you to our sponsors:

• NAD + Cell Shield from Biostack Labs https://biostacklabs.com/kris 

• BiOptimizers - code KRIS10 for 10% off  https://bioptimizers.com/ 

My Go-To for Muscle Building: Isolate + CreGaatine + Dileucine from Unmatched Supplements https://www.unmatchedsupps.com/collections/muscle-building

My Go-To for Gut Health: Glutamine and Imuno-IGG from Unmatched Supplements: https://www.unmatchedsupps.com/collections/digestion-gut-health 

 

Find more from Kris:

Website: https://www.krisgethin.com/ 

Instagram: @krisgethin 

Youtube: https://www.youtube.com/krisgethin