Energized with Dr. Mariza

693: Tired All the Time? It Might Be Hidden Problems With Your Mitochondria with Siobhan Mitchell

Nov 11, 2025
Neuroscientist Siobhan Mitchell, Chief Scientific Officer at MitoQ, dives into the crucial role mitochondria play in aging and energy levels. She highlights how perimenopause is more than hormonal shifts; it's a significant neuroendocrine transition affecting mental and physical vitality. Siobhan reveals the benefits of MitoQ, an antioxidant that enhances mitochondrial function, and discusses the impact of lifestyle on menopause outcomes. Tune in for insights on how to optimize energy, mood, and longevity during midlife!
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INSIGHT

Menopause Is A Brain Transition

  • Menopause is a neuroendocrine brain transition, not just hormonal changes.
  • Loss of estrogen impairs mitochondrial function and glucose metabolism in the brain, raising cognitive decline risk.
INSIGHT

Estrogen Use Correlates With Longevity

  • Preserving estrogen function after menopause links to longer female lifespan in epidemiological data.
  • UK Biobank showed estrogen-associated drugs correlated with increased longevity in women.
INSIGHT

Mitochondria Influence Social Anxiety

  • Mitochondrial activity in the amygdala links to social anxiety and stress responses.
  • Ketone sources (MCTs) calmed overactive mitochondria in animal models and reduced anxiety-like behavior.
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