
The Dr. Josh Axe Show The Testosterone, Weight Loss & Hormone Lies Your Doctor Never Told You | Brigham Buhler
Oct 1, 2026
Brigham Buhler, healthcare entrepreneur and founder of Ways2Well and Revive Rx, challenges conventional healthcare economics and one-size-fits-all treatment. He explores plasma exchange, ozone therapy, advanced testing, GLP-1 dosing, testosterone and peptide access, and the influence of pharmacy benefit managers. The conversation also examines FDA policy, compounded medications, cash-pay care, and the tension between regulation, innovation, and patient choice.
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How Insurance Limits Preventive Testing
- Insurance restrictions can limit preventive care even when clinicians want to order comprehensive testing.
- Brigham Buhler created a cash-pay lab after Texas doctors reported threats for ordering full blood panels.
Personalize Supplements With Testing
- Use genetic and metabolic testing to individualize supplements instead of taking large amounts indiscriminately.
- Josh Axe and Brigham Buhler noted that MTHFR variants and different NAD forms can produce dramatically different responses.
Jelly Roll Used Plasma Exchange During Weight Loss
- Brigham Buhler described using plasma exchange during major weight loss to address inflammation, bloating, and circulating toxins.
- He said Jelly Roll reported sleeping above 80 on his tracker for the first time in years after treatment.

