Hormones, the Immune System & Autoimmunity | Ep 168

11 snips

Aug 24, 2021

Dive into the fascinating interplay between hormones and the immune system. Explore how estrogen and progesterone influence autoimmunity, with insights on why estrogen sometimes gets a bad rap. Discover essential details about the body's first line of defense, secretory IgA, and how cortisol affects health. Erin also sheds light on the impact of alcohol on hormones and shares tips on the best exercises for hormonal balance. Perfect for anyone, especially women, keen to understand their health better!

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INSIGHT

Estrogen Balances Immune Response

Estrogen supports immune balance by suppressing overactive antigen-presenting cells like dendritic cells.
It inhibits inflammatory cytokines, preventing immune overreactions linked to autoimmunity.

INSIGHT

Estrogen & Immune Regulation

T-regulatory cells act as referees to maintain immune response balance and estrogen supports their function.
The AIRE protein in the thymus helps train T cells to avoid attacking the body, with estrogen influencing this process.

INSIGHT

Pregnancy Immune Shift and Autoimmunity

Pregnancy shifts immune response from Th1 to Th2 dominance to prevent attacking the fetus.
Autoimmune symptoms can improve or worsen during pregnancy depending on if the condition is Th1 or Th2 dominant.

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Today’s episode gets into details about hormones and the immune system. Erin unpacks general immunity questions & how hormones can affect immunity, and also gets into the relation between hormones and autoimmunity.

If you’re someone who struggles with autoimmunity, this will be an interesting episode to tune into. This episode is geared more towards women, female hormones, and the impact this can have on the immune system, so share this with the women in your life - Erin covers some of the most important things to get under control in regards to overall health, immune health, and to current events.

In this episode: -Feedback from the last episode [3:06]

-*NEW* details about Your Hormone Revival™ [5:04]

-Hormones, the immune system and autoimmunity [10:33]

-Why estrogen sometimes gets a bad rep [11:54]

-Antigen presenting cells (APCs) [13:08]

-T Reg cells & AIRE on the immune system & autoimmunity [17:08]

-Pregnancy and autoimmunity [20:18]

-Why estrogen might make you feel better or worse depending on your situation [22:34]

-Symptoms associated with low estrogen [27:02]

-Alcohol intake and hormonal issues [28:24]

-Why progesterone is the "chill" hormone [30:03]

-What to consider with cortisol [31:55]

-Secretory IgA: the body’s first line of defense [34:04]

-What’s the best exercise from a hormone standpoint? [38:10]

-Cortisol Awakening Response (CAR) [42:53]

-Signs your CAR might be low [44:17]

Resources mentioned:

Your Hormone Revival™ (Registration opens to the waitlist Sept 1st!) https://www.erinholthealth.com/hormones

Estrogen, A Double-Edged Sword: Modulation of TH1- and TH2-Mediated Inflammations by Differential Regulation of TH1 / TH2 Cytokine Production https://www.ingentaconnect.com/content/ben/cdtia/2004/00000003/00000001/art00010

Autoimmune Disease in Women: Endocrine Transition and Risk Across the Lifespan https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501433/

Are You Th1 or Th2 Dominant? Effects + Immune Response https://selfhacked.com/blog/supplements-foods-exercise-right-type-th1-vs-th2-dominance/

Organifi supplement powder (save 20% on your order with code FUNK) https://organifi.com/FUNK

Bio-Kult Boosted probiotic (save 15% on your order with code FUNK15) https://www.bio-kult.com/bio-kult-boosted/p9

Coyote River Hemp Co CBD (save 10% & free shipping on your order with code FUNK10) https://coyoteriverhempco.com/

Related episodes: 72: Exercising with “Adrenal Fatigue” & Cortisol Dysregulation https://www.erinholthealth.com/funktional-nutrition-podcast/2019/10/16/episode-72-exercising-with-adrenal-fatigue-amp-cortisol-dysregulation

82: Cortisol, DHEA + Adrenal Testing, Part 1 https://www.erinholthealth.com/funktional-nutrition-podcast/2020/1/16/w96fndlyzhz5f71t2xpqbffjvp4nav

83: Cortisol, DHEA + Adrenal Testing, Part 2 https://www.erinholthealth.com/funktional-nutrition-podcast/2020/1/22/episode-83-cortisol-dhea-adrenal-testing-part-2

112: All Your Cortisol Qs Answered, Part 1 https://www.erinholthealth.com/funktional-nutrition-podcast/2020/8/5/episode-112-all-your-cortisol-questions-answered-part-1

113: All Your Cortisol Qs Answered, Part 2 https://www.erinholthealth.com/funktional-nutrition-podcast/2020/8/11/episode-113-all-your-cortisol-questions-answered-part-2

137: Is Perfectionism Driving Your Hormone Imbalance? Cortisol, DHEA + Adrenal Testing https://www.erinholthealth.com/funktional-nutrition-podcast/2020/12/29/episode-137-is-perfectionism-driving-your-hormone-imbalance-cortisol-dhea-adrenal-testing

165: Hormone Lab Testing, Estrogen Dominance & Balancing Your Hormones at Home https://www.erinholthealth.com/funktional-nutrition-podcast/2021/7/29/episode-165-hormone-lab-testing-estrogen-dominance-amp-balancing-hormones-at-home