Nutrition Facts with Dr. Greger The Risks and Benefits of Nicotinamide
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Sep 4, 2025 Dive into the world of nicotinamide, a supplement touted for boosting NAD+ levels. Discover its historical significance and the ongoing debate about its health effects and safety. The discussion contrasts findings from animal studies with human trials, raising important questions about its efficacy. Explore the biochemical mechanisms behind nicotinamide and its potential role in aging. It's a fascinating look at whether this supplement is a health boon or a risk.
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NAM Versus Niacin: Same Vitamin, Different Effects
- Nicotinamide (NAM) and nicotinic acid (NA) are both called niacin but act differently in the body.
- NAM has mixed evidence: extends C. elegans lifespan but failed to prolong mouse lifespan and often doesn't raise muscle NAD in healthy humans.
Methylation Risks From Excess NAM
- High-dose nicotinamide can cause GI problems, liver toxicity, and methylation strain from converting excess NAM to methyl nicotinamide.
- Methyl nicotinamide is neurotoxic and may cross the blood-brain barrier, potentially worsening Parkinson-like pathology.
Small Doses Can Affect Methylation
- Even modest single doses of NAM (as low as 100 mg) can impair methylation pathways in humans.
- A single 100 mg dose raised norepinephrine, serotonin, histamine, and homocysteine, indicating disrupted breakdown and increased cardiovascular risk markers.
