Dr. Joseph Mercola - Take Control of Your Health Does Melatonin Help Ease Migraines?
Oct 3, 2025
Explore how melatonin can ease migraine symptoms for millions worldwide. Discover its surprising benefits beyond sleep regulation, including cellular protection and inflammation reduction. Research reveals that 3 mg of melatonin may significantly decrease headache frequency and intensity. Learn about its safety compared to common medications and the optimal timing for use. The hosts also discuss practical strategies for enhancing your melatonin production, making this a must-listen for those seeking natural migraine relief.
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Two Sources Of Melatonin
- Melatonin has dual sources: pineal release for sleep and mitochondrial production for cellular protection.
- Mitochondrial melatonin acts locally as an antioxidant and shields brain cells tied to migraine biology.
Melatonin Links To Migraine Biology
- Low or disrupted melatonin links to migraine risk via sleep and hormonal pathways.
- Outcome trials are more informative than mixed melatonin level studies for migraine effects.
Clinical Trials Show Big Reductions
- A pooled review found melatonin reduced frequency by ~51%, intensity by ~53%, and duration by ~46%.
- Many participants cut monthly migraines by half and used fewer rescue medications.