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PedsCrit

Acute Kidney Injury with Dr. Archana Dhar and Dr. Molly McGetrick, Part 3

Oct 4, 2021
Dr. Archana Dhar and Dr. Molly McGetrick discuss Acute Kidney Injury (AKI) in the pediatric critical care setting, including diagnosing AKI according to the KDIGO guidelines, the use of biomarkers and the renal angina index for risk stratification, and therapeutic agents such as low dose dopamine. They also highlight the importance of vigilance and monitoring urine output in the ICU population.
22:11

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Quick takeaways

  • The Renal Angina Index is a useful tool for risk stratification and early identification of acute kidney injury (AKI), taking into account various factors such as mechanical ventilation, serum creatinine levels, and fluid accumulation.
  • Studies like the AWARE study and the Awakened Trial emphasize the negative long-term outcomes of AKI in children, including increased mortality rates, chronic hypertension, and renal disease, highlighting the importance of early identification and management.

Deep dives

The Renal Angina Index and its Role in Predicting AKI

The Renal Angina Index is a stratification tool used to score patients based on their risk and injury severity, which helps predict the development of acute kidney injury (AKI). The index takes into account factors such as the need for mechanical ventilation or vasoactive medications, history of organ or stem cell transplant, and ICU admission. It also considers serum creatinine compared to baseline levels and percentage of fluid accumulation. The index scores patients on a scale of 1 to 40, with a score of 8 or higher indicating renal angina. Several centers, such as Cincinnati, utilize this index to determine the need for early continuous renal replacement therapy (CRRT) or other interventions like the Lasix Challenge Test. The Renal Angina Index has been shown to be a sensitive and specific marker for early identification of renal injury.

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