Acute Kidney Injury with Dr. Archana Dhar and Dr. Molly McGetrick, Part 3
PedsCrit
Therapeutic agents and challenges in acute kidney injury
Discussion on the effectiveness of low dose dopamine and phenoltopam in improving renal blood flow in patients with acute kidney injury (AKI). Mention of a recent study on the use of a lasix challenge and the current guidelines from ADIGO.
Dr. Dhar is a is an Associate Professor of Pediatrics and practicing pediatric intensivist at Children’s Medical Center and UT Southwestern in Dallas.
Dr. McGetrick recently completed her pediatric critical care fellowship training at UT Southwestern and is a current pediatric cardiovascular ICU fellow at Texas Children’s.
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After listening to this series of episodes, learners should be able to:
- Define AKI.
- Discuss incident and epidemiology of AKI in the pediatric critical care setting.
- Know how to diagnose AKI according to the KDIGO guidelines.
- Recall the role of biomarkers and renal angina index in risk stratification and early identification of AKI.
- Discuss a clinical approach to managing a patient with acute kidney injury.
References:
Sethi SK, Bunchman T, Chakraborty R, Raina R. Pediatric acute kidney injury: new advances in the last decade. Kidney Res Clin Pract. 2021 Mar;40(1):40-51. doi: 10.23876/j.krcp.20.074. Epub 2021 Mar 3. PMID: 33663033; PMCID: PMC8041642.
Alobaidi R, Anton N, Burkholder S, Garros D, Garcia Guerra G, Ulrich EH, Bagshaw SM. Association Between Acute Kidney Injury Duration and Outcomes in Critically Ill Children. Pediatr Crit Care Med. 2021 Feb 26. doi: 10.1097/PCC.0000000000002679. Epub ahead of print. PMID: 33729733.
Kaddourah A, Basu RK, Bagshaw SM, Goldstein SL; AWARE Investigators. Epidemiology of Acute Kidney Injury in Critically Ill Children and Young Adults. N Engl J Med. 2017;376(1):11-20. doi:10.1056/NEJMoa1611391
Hessey E, Melhem N, Alobaidi R, Ulrich E, Morgan C, Bagshaw SM, Sinha MD. Acute Kidney Injury in Critically Ill Children Is Not all Acute: Lessons Over the Last 5 Years. Front Pediatr. 2021 Mar 15;9:648587. doi: 10.3389/fped.2021.648587. PMID: 33791260; PMCID: PMC8005629.
Basu RK, Kaddourah A, Terrell T, et al. Assessment of Worldwide Acute Kidney Injury, Renal Angina and Epidemiology in critically ill children (AWARE): study protocol for a prospective observational study. BMC Nephrol. 2015;16:24.
Schneider J, Khemani R, Grushkin C, Bart R. Serum creatinine as stratified in the RIFLE score for acute kidney injury
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Thank you for listening to this episode of PedsCrit. Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at pedscritpodcast@gmail.com. Check out http://www.pedscrit.com for detailed show notes. And visit @critpeds on twitter and @pedscrit on instagram for real time show updates.
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