The Intern At Work: Internal Medicine cover image

The Intern At Work: Internal Medicine

183. An Approach to PCOS

Feb 19, 2023
13:29

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Quick takeaways

  • PCOS involves disruptions in hormone levels affecting ovulation and androgen conversion.
  • Diagnosis requires meeting specific criteria with emphasis on history, physical examination, and ruling out other conditions.

Deep dives

Understanding PCOS Pathophysiology

Polycystic ovary syndrome (PCOS) is characterized by various mechanisms, including disruptions in the hypothalamic-pituitary-ovarian axis. Changes in follicular development, such as lack of ovulation leading to lower progesterone and increased LH levels, contribute to the syndrome. Additionally, conversion of adrenal androgens into estrone in peripheral tissues and associations with hyperinsulinemia are key pathophysiological pathways of PCOS.

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