Introduction

Polycystic ovary syndrome or PCOS was first described in 1721 by an Italian scientist named Antonio Velus Nary. The pathophysiology of PCOS is still a matter of debate, let us first review the normal hypothalamic pituitary ovarian axis to understand proposed mechanisms. Hyperinsulinemia with insulin resistance is considered one of the most important factors that predispose people with ovaries to PCOS because it promotes hyperandrogenism and chronic and ovulation.