• Why uncoupling is harmful in certain contexts and how PUFA cause constant, low-level uncoupling
  

• The involvement of uncoupling, mitochondrial biogenesis, autophagy, heat shock proteins, and hypoxia-inducible factors in the stress response

• How stress prevents our mitochondria from effectively producing energy

• How chronic stress causes insulin resistance, high blood pressure, weight gain, depression, and cardiovascular disease

• How sugar and fat cravings result from stress and why listening to them is beneficial

• How adaptations to stress get passed on through generations

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Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-94-how-stress-crashes-your-metabolism-why-hormesis-is-not-the-answer-stress-mitochondria-part-2/

Timestamps:

0:00 – intro 

2:59 – the details of how mitochondrial respiration can become disrupted, especially from glucocorticoids

6:05 – the short-term effects of catecholamines

8:34 – why uncoupling is harmful in certain contexts and how PUFA cause constant, low-level uncoupling

14:40 – the protective effects of uncoupling as a part of the stress response

20:08 – the role of cytokines (TNF-alpha, IL-1, IL-6, heat-shock proteins, NF-kB, HIF) in the stress response

37:33 – the effect of acute stress on energy production in mitochondria

45:18– the effect of chronic stress on energy production in mitochondria

48:15 – how stress drives degeneration and the evidence for increased activity of hormetic pathways (including effects like mitochondrial biogenesis and autophagy) in degenerative states

1:05:24 – the relationship between mental health, mood, and metabolic function

1:10:21 – how adaptations to stress get passed on through mitochondrial DNA

1:18:32 – how to best improve mitochondrial function and our health