The Dr. Tyna Show

GLP-1s, Muscle, and the Brain: The Real Magic of Metabolic Medicine | Dr. William Seeds

11 snips
May 22, 2025
Dr. William Seeds, a board-certified orthopedic surgeon and founder of the Seeds Scientific Research and Performance Institute, shares his expertise on peptides and GLP-1s. He discusses their impact beyond weight loss, including neuroplasticity and behavior change. Essential insights on pairing GLP-1s with strength training for fat loss are explored, along with risks of overuse. Additionally, he highlights the importance of personalizing GLP-1 dosing based on individual metabolism and sensitivity. Tune in for a deep dive into metabolic medicine!
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INSIGHT

GLP-1s Control Appetite via Brain

  • GLP-1 peptides reduce appetite by modulating brain pathways that control hunger signals.
  • This appetite suppression helps correct overeating behaviors driven by nutrient surplus and dopamine-related addiction.
ANECDOTE

Patients Relearn Appetite Control

  • Some patients decreasing GLP-1 dosage learned to control hunger intentionally through new behaviors.
  • They gained control over appetite where previously they had none, showcasing neuroplasticity.
INSIGHT

GLP-1s Reduce Brain Inflammation

  • GLP-1 receptors in brain and kidney cells reduce inflammation and improve mitochondrial efficiency.
  • Improving cell redox states via GLP-1s controls inflammation systemically and preserves kidney function.
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