535: A longevity drug exists—would you take it? | Nir Barzilai, M.D., leading longevity researcher 

“We have to spend time on our health rather than spend time on diseases," says Nir Barzilai, M.D.

Nir, a renowned longevity researcher, joins us to discuss pharmaceutical interventions to delay aging, plus:

- What are gerotherapeutics? (~00:19)

- What you need to know about antagonistic nutrients (~04:25)

- Why healthcare costs don’t have to increase as people live longer (~08:55)

- SuperAgers vs. Blue Zones (~12:40)

- What are some science-backed longevity genes? (~15:14)

- The hallmarks of aging (~19:54)

- How metformin extends longevity (~22:46)

- Who is the right candidate for longevity drugs? (~25:03)

- The best age to take a longevity drug (~31:55)

- Lifestyle interventions for healthy aging (~34:17)

- Is fasting actually necessary? (~38:18)

- What to know about mTOR (~41:19)

- How to test your biological age (~43:10)

- What to do in your 20s and 30s for healthy aging (~48:16)

- The role of mindset in aging (~53:45)

- How repurposing drugs has saved lives (~57:45)

- Why women have the aging advantage (~01:03:42)

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Referenced in the episode:

- Nir's book, Age Later

- Nir's SuperAger study

- The SuperAgers family study

- Learn about the antagonistic pleiotropy hypothesis of aging

- Nir's study on metformin & aging

- TAME trial

- A study on metformin & COVID outcomes

- A study on metformin & muscle hypertrophy

- Nir's study on organ aging

- A study on metformin & IGF1

- A study on centenarians & IGF1

- Episodes #363, #217 & #170, with David Sinclair, Ph.D.

- Episode #207, with David Fajgenbaum, M.D., MBA, M.Sc., FCPP

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