This Podcast for the Neurology Journal begins with Dr. John H. Noseworthy, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Jason Mackey interview Dr. Magdy Selim about his paper on predicting hemorrhage after thrombolysis. In the next segment, Dr. Ryan Overman is reading our e-Pearl of the week about a pearl and an oy-ster in headache: The 50-50 rule. The podcast concludes with Dr. Michael Benatar interviews Dr. Michael McDermott on the topic of ROC curves for the Lesson of the Week segment. The participants had nothing to disclose.