The sweeping reorganisation of the brain in pregnancy, and why it matters
Sep 19, 2024
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Dr. Laura Pritschet, a postdoctoral fellow in psychiatry at the University of Pennsylvania, reveals groundbreaking research on brain changes during pregnancy. She discusses how continuous scans showcase dynamic transformations that enhance maternal abilities rather than indicate decline. The conversation highlights the historical neglect of women's health in neuroscience, calling for more attention to female-specific issues. These insights could improve our understanding of maternal mental health challenges, like postpartum depression.
Pregnancy induces significant brain reorganization, marked by gray matter reduction and white matter integrity enhancement, affecting maternal behavior and cognition.
The historical oversight of women's health in neuroscience necessitates dedicated research to improve understanding and treatment of pregnancy-related conditions.
Deep dives
Investigating Maternal Brain Changes
Research has revealed that pregnancy induces significant changes in the human brain that have not been thoroughly documented before. A study involving extensive brain scans of a single subject—conducted 26 times throughout her pregnancy—provided unprecedented insight into these transformations. It was found that approximately 80% of the brain's regions showed a reduction in gray matter as gestational weeks progressed, with some degree of recovery postpartum. This process may not be negative; instead, it could represent a fine-tuning of neural circuits akin to developmental changes seen during puberty.
Shifts in Brain Structure During Pregnancy
Alongside reductions in gray matter, the study observed an increase in white matter microstructure throughout the brain, suggesting improved connectivity among neurons. This interplay between decreasing gray matter volume and increasing white matter integrity indicates a complex biological response to pregnancy. It showcases the brain's ability to adapt and reorganize in response to hormonal changes, with implications for understanding maternal behavior and cognitive functions. Importantly, these findings challenge the fear associated with gray matter loss, hinting at a beneficial process of neural optimization.
Addressing Gender Bias in Medical Research
Historically, women's health issues have been overlooked in biomedical research, leading to a gap in understanding how conditions like pregnancy affect the female brain. This neglect has implications for drug regulation and health outcomes, as evidenced by a report highlighting that recent FDA drug withdrawals were largely due to untested effects on women. Increasing awareness and conducting dedicated research on female-specific health conditions are essential for developing effective treatments. The ongoing maternal brain project aims to rectify this oversight by expanding the research scope to include diverse cohorts and clinical populations.
Ian Sample talks to Dr Laura Pritschet, a postdoctoral fellow of psychiatry at the University of Pennsylvania, about her research using precision scans to capture the profound changes that sweep across the brain during pregnancy. She explains what this new work reveals about how the brain is reorganised in this period, whether it could it help us better understand conditions like pre-eclampsia and postnatal depression, and why women’s brains have often been overlooked by neuroscience. And neuroscientist Dr Liz Chrastil whose brain was scanned, explains what the experience was like. Help support our independent journalism at theguardian.com/sciencepod
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