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Evolution of AKI Terminology
- The terminology for acute kidney injury (AKI) evolved from 'war nephritis' to 'lower nephron nephrosis' to 'acute renal failure' and finally to 'acute kidney injury' in 2006.
- This change reflects a consensus that even minor kidney function changes significantly impact outcomes.
Kidney Roles and AKI Impact
- Kidneys filter about 200 liters of blood daily and regulate electrolytes, blood pressure, vitamin D, and red blood cell production.
- AKI causes rapid kidney function loss, leading to waste buildup and electrolyte/water imbalances.
AKI Causes Framework
- AKI causes are categorized into pre-renal (blood flow reduction), renal (intrinsic kidney damage), and post-renal (urine obstruction).
- Multiple conditions affect each category, aiding targeted diagnosis and treatment.