Lifespan with Dr. David Sinclair

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The Science of Looking Younger, Longer | Episode 6

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Feb 9, 2022

Guest

David Sinclair

01:09:57

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INSIGHT

Early Signs of Aging in Women

Menopause is often the first noticeable sign of aging in women, affecting the reproductive system earlier than other organs.
This can manifest before signs of aging appear in the heart, lungs, or brain.

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ADVICE

Baseline Hormone Levels

Women should measure their estrogen and progesterone levels in their 30s and 40s to establish a baseline.
This allows physicians to personalize hormone replacement therapy later in life, matching natural levels and minimizing potential side effects.

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INSIGHT

Epidermal Thinning and Aging

Epidermal thinning is a common effect of aging, accelerated by menopause.
It's not just a cosmetic issue, but a health concern, increasing vulnerability to injuries and infections.

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Boosting the Body's Aging Efforts

01:47 • 2min

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How to Reverse Female Infertility

03:33 • 2min

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Metaposl Hormone Therapy

05:46 • 2min

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The Dangers of Hormone Replacement Therapy

07:45 • 2min

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The Epidermal Thinning Effect During Menapause

Is Your Skin Thinning?

Are You Really as Old as You Look?

The Effects of Senelitic Drugs on Aging Skin

23:20 • 2min

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The Effects of U v Light on the Skin

25:10 • 3min

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Getting Rid of Those Thymen Dimes Ar

27:42 • 2min

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Is Collegin a Good Beauty Product?

29:34 • 2min

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Retinoids Are a Great Anti-Occurrence and Anti-Aging Solution for Your Skin

31:05 • 3min

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The Rate of Your Nail Growth Is a Good Indicator of Aging

33:39 • 2min

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Retinoids, Longevity Mechanism

35:41 • 2min

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Therar Topical Creams

37:53 • 2min

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Is There a Way to Prevent Cancer in the Skin?

39:55 • 2min

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Anti Aging Implications of Botox

41:45 • 2min

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I've Never Had Micro Needling Done, of You

43:35 • 2min

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Hair Loss and Hair Graying

45:09 • 2min

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Is It Dangerous to Lose Hair?

46:48 • 3min

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Do Topical Retinol Creams Really Work?

Eunuchs Live Longer Than Regular Men

53:08 • 2min

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Is There a Side Effect to Propetia?

54:44 • 3min

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Rejuvenating Stem Cells

57:22 • 2min

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Is There an Anti Aging Pathway in the Peripe?

59:08 • 2min

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Is Stress Associated With Aging?

01:01:05 • 2min

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Is There a Drug That Can Reset Themselves?

01:03:17 • 1min

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Is Cyclosporna Rejuvenating Hair Colour?

01:04:46 • 2min

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Is There a Future for Reverse Aging?

01:07:09 • 3min

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In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. The latest science behind various beautifying therapies is highlighted, including newer interventions like low-level laser therapy and platelet-rich plasma injections.

Thank you to our sponsors:

Athletic Greens - https://athleticgreens.com/sinclair
Levels - https://levels.link/sinclair
InsideTracker - https://insidetracker.com/sinclair

Our Patreon page: https://www.patreon.com/davidsinclair

Lifespan book: https://amzn.to/3sUqurT

Dr. David Sinclair Social:

Instagram
Twitter
Facebook

Matthew LaPlante's Social:

Twitter

To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.

Timestamps:

(00:00:00) Launching Episode Six: Combating Cosmetic Aging & Improving Skin, Nails & Hair

(00:02:54) Estrogen, Progesterone, and Menopause

(00:09:51) Thanking the Sponsors

(00:12:57) The Pinch Test, Epidermal Thinning, and Foot Ulcers

(00:18:29) Skin and Biological Aging

(00:23:19) Cellular Senescence, Ultraviolet Light, and Skin Aging

(00:28:15) Collagen, Keratin, and Skin Health

(00:33:38) A Quick Aside about Nails

(00:34:45) Autophagy and Retinoids

(00:36:57) Resveratrol, NAD Boosters, and Hyaluronic Acid

(00:41:44) Botox, Skin Peels, and Microneedling

(00:43:28) No Duh Stuff: Sun Damage, Smoking, Alcohol, and Bad Food

(00:45:42) Hair Loss and Hair Graying

(00:49:45) Topical Treatments, Pills, and Dihydrotestosterone

(00:55:19) Frickin Laser Beams: Low-level Laser Therapy

(00:57:59) Platelet-rich Plasma (PRP) Injections

(01:00:11) Hair Aging, Stress, and Gray Hair Reversal

(01:06:11) Targeting Aging Upstream

(01:07:37) Today’s Takeaways

(01:09:25) Subscription and Support Options

For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

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