Stem Cell Treatment Shows Potential for Restoring Fertility in Women with Ovarian Failure

BUFFALO, NY — July 21, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 6, on June 27, 2025, titled “Enhancing oocyte activation in women with ovarian failure: clinical outcomes of the Stem Cell Regenera study using G-CSF mobilization of peripheral blood stem cells and intraovarian injection of stem cell factor-enriched platelet rich plasma in real-world-practice.” This study, led by Amparo Santamaria with co-authors Ana Ballester and Manuel Muñoz from IVI Clinics Alicante, evaluates the effectiveness and safety of a regenerative treatment that may enable women with ovarian failure to regain the ability to produce viable eggs. The approach combines stem cell mobilization and enriched plasma injections into the ovaries to stimulate follicle growth. It provides an alternative for patients experiencing infertility due to poor ovarian response, diminished ovarian reserve, or premature ovarian insufficiency. Researchers evaluated the Stem Cell Regenera treatment in 145 women, aged 26 to 44 years, who had not responded to conventional fertility therapies. The procedure involved mobilizing the body’s own stem cells using granulocyte colony-stimulating factor (G-CSF), followed by an injection of platelet-rich plasma enriched with stem cell factors directly into the ovaries. This method was designed to activate dormant follicles and promote ovarian regeneration. Nearly 70% of participants demonstrated oocyte activation, defined as increased follicle growth or a rise in key hormone levels. Approximately 7% achieved spontaneous pregnancies, and 14% conceived through in vitro fertilization (IVF) after treatment. These results indicate that the therapy stimulates ovarian activity and may increase the chances of conception in selected patients. “The primary outcome measures were the rate of oocyte activation, leukocytes and stem cell count, and pregnancy rates.” No severe adverse effects were reported. Most participants tolerated the treatment well, with only mild and transient symptoms such as headaches or fatigue. The use of the patient’s own cells minimized the risk of immune reactions and helped ensure the treatment was safe. The findings provide evidence of effectiveness and safety for the Stem Cell Regenera protocol in a clinical setting. While the study was retrospective observational, the outcomes support further investigation through larger controlled trials to confirm long-term benefits and identify which patient populations may gain the greatest benefit from this approach. This research contributes to the growing field of regenerative medicine in reproductive health, offering clinicians additional tools to address infertility in women with complex ovarian conditions. DOI - https://doi.org/10.18632/aging.206274 Corresponding author -Amparo Santamaria - Amparo.santamaria@ivirma.com Author interview - https://www.youtube.com/watch?v=oRFJNwnXZWI Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206274 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, Stem Cell Regenera, oocyte activation, ovarian regeneration, G-CSF, SCFE-PRP, ovarian failure To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM