

When Harry Became Sally | Interview: Carole Hooven
Aug 21, 2025
Carole Hooven, an evolutionary biologist and author of 'T: The Story of Testosterone,' dives deep into the intricate complexities of gender and sex. She discusses how testosterone shapes behavior and gender differences, alongside the impacts of historical context on modern gender identities. Hooven challenges societal narratives, emphasizing the significance of respectful discourse in discussing transgender issues. The conversation also explores the cultural influences on male sexual behavior and the science of epigenetics, revealing how our biology and environment intertwine.
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Early Testosterone Shapes Sexed Development
- Testosterone exposure begins in utero and shapes permanent differences in brain and body development between males and females.
- These hormonal effects create male and female developmental pathways tied to reproductive function and behavior.
Child Play Reflects Biology Not Just Culture
- Childhood play differences (e.g., boys wrestling) appear across cultures and in animals, showing biological mediation by hormones.
- Manipulating early hormone exposure in animals alters play, supporting biological roots of some sexed behaviors.
Gametic Definition Clarifies Sex
- Sex is best defined by gamete-producing roles: sperm producers (males) and egg producers (females).
- This gametic definition predicts many other sex-associated traits across sexually reproducing species.