
Alpha-Synuclein Overexpression in Rats Reveals Early Clues to Synucleinopathies
Nov 11, 2025
04:48
Synucleinopathies are a group of age-related neurological disorders, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy. Most individuals are not diagnosed until these diseases have significantly progressed, as early symptoms, such as a reduced sense of smell, subtle cognitive or motor changes are too vague to serve as reliable indicators.
To uncover specific biological signs that appear earlier and clearly point to the disease process, researchers from Saarland University developed a study titled “Brain region-specific and systemic transcriptomic alterations in a human alpha-synuclein overexpressing rat model,” featured as the cover Aging-US, Volume 17, Issue 10.
Full blog - https://aging-us.org/2025/11/alpha-synuclein-overexpression-in-rats-reveals-early-clues-to-synucleinopathies/
Paper DOI - https://doi.org/10.18632/aging.206331
Corresponding author - Thomas Hentrich - thomas.hentrich@uni-saarland.de
Abstract video - https://www.youtube.com/watch?v=Yl6AfVchkb0
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Keywords - aging, alpha-synuclein, transgenic rat model, different brain regions, transcriptome analysis
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