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Business Of Biotech
Manufacturing Partnership With Life Biosciences' Jerry McLaughlin and Forge Biologics' John Maslowski
Dec 9, 2024
Jerry McLaughlin, CEO of Life Biosciences, and John Maslowski, newly appointed CEO of Forge Biologics, delve into groundbreaking topics in biotech. They discuss advancements in partial epigenetic reprogramming therapies and their collaboration on clinical trials. The conversation also highlights strategic growth and leadership changes at Forge after its acquisition. Insights into the thriving biotech environment in Columbus are shared, emphasizing the importance of trust and communication in successful partnerships within the sector.
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Quick takeaways
- Life Biosciences aims to lead with ER100, a promising therapy for optic neuropathies, targeting clinical trials by mid-2025.
- The partnership with Forge Biologics is built on thorough CDMO selection and shared values to advance innovative therapies efficiently.
Deep dives
Advancements in Epigenetic Reprogramming
Life Biosciences is on track to be the first company to enter the clinic with a partial epigenetic reprogramming therapy, known as ER100, which targets optic neuropathies. With an IND filing planned for mid-2025, the company has made significant strides from earlier data in mouse models to promising results in a non-human primate study. The therapy demonstrated the ability to restore visual function and preserve retinal ganglion cells, showcasing potential efficacy in treating conditions like primary open-angle glaucoma. This transition represents a critical milestone for Life Biosciences as they prepare for larger clinical studies and aim to bring their innovative treatment to the market.
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