Docs Who Lift GLP-1 and metabolism and depression
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Apr 11, 2025 Explore the fascinating effects of tirzepatide on metabolic rates and its surprising links to depression. Discover the real-life implications and psychological risks of GLP-1 medications like semaglutide. Delve into personal stories of overcoming weight loss plateaus through the interplay of mental and physical health. Learn about the costs and accessibility challenges of obesity treatments, and how these affect patients' ability to maintain their health. Join the conversation on modern solutions and the future of diabetes management!
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Tirzepatide's Impact on Weight Loss
- Tirzepatide's efficacy over calorie restriction: Patients report significant weight loss despite consuming few calories.
- This challenges the energy balance principle, suggesting additional weight loss mechanisms beyond reduced intake.
Metabolic Rate and Tirzepatide
- Increased metabolic rate as a potential mechanism: There's speculation that tirzepatide increases metabolic rate, contributing to weight loss.
- However, studies have shown that metabolic adaptation still happens; it's just that patients eat fewer calories due to appetite suppression.
Tirzepatide, Anhedonia, and Bupropion
- A patient on 15mg of tirzepatide experienced anhedonia and loss of motivation to exercise.
- Reducing the dose to 10mg and adding bupropion helped her regain motivation, break her weight loss plateau, and lose an additional 10 pounds.