
What's That Rash? Do the benefits of creatine go beyond the gym?
Dec 9, 2025
Creatine is not just for muscle gain; it may enhance brain function and tackle menopause symptoms. The hosts dive into its potential benefits against dementia and cognitive decline. They also discuss the limitations of current research, highlighting small sample sizes and conflicts of interest. Concerns about creatine's possible link to cancer are examined, along with important safety considerations. Lastly, they stress the value of dietary protein and consulting professionals before jumping into supplementation.
AI Snips
Chapters
Books
Transcript
Episode notes
Creatine Is An Energy Buffer Throughout The Body
- Creatine acts as an energy buffer by storing and releasing phosphate groups to regenerate ATP when cells need bursts of energy.
- This phosphocreatine system operates in muscle and in other tissues including the brain and heart.
Brain Creatine Is Plausible But Understudied
- Creatine and brain creatine kinase exist and support energy production in the brain, making it plausible as a cognitive intervention.
- However, most creatine research focuses on muscle, so brain-related evidence is limited and lower quality.
Perimenopausal Buzz Around Creatine
- Tegan recounts a friend in her 40s saying creatine is trending among female athletes and YouTubers, especially in perimenopausal circles.
- That social buzz partly explains why many listeners asked about creatine beyond muscle use.


