Drs. Karl and Spencer discuss the FLOW trial showing kidney protection with semaglutide, rant about costly medicines, compounding considerations, and the need for heart and kidney health focus in diabetes management.
Semaglutide in the FLOW trial showed kidney protective effects.
The podcast emphasizes the importance of diabetes medications in kidney protection.
Deep dives
Overview of the Flow Trial and Renal Outcomes
The podcast discusses the Flow Trial using Ozempic at one milligram and its findings on kidney outcomes, indicating its kidney protective effects. It highlights the increased risks of heart and kidney diseases associated with obesity and diabetes, emphasizing the significance of cardioreno focus in managing these complications.
Importance of Diabetes Medications in Kidney Protection
The podcast explains the importance of diabetes medications in protecting the kidneys, citing the significance of hyperglycemia in increasing the risk of microvascular complications and kidney disease. It underscores the role of standard kidney-protective medications and the recent advancements in diabetes medications showing benefits for heart and kidney health.
Characteristics of Participants in the Trial
The podcast details the characteristics of patients in the trial, highlighting their high risk factors like obesity, type 2 diabetes, chronic kidney disease, and protein in urine. It notes the global representation of participants and the average data on age, hemoglobin A1c levels, kidney disease stages, and smoking status.
Safety and Efficacy of Semaglutide in the Trial
The podcast discusses the safety and efficacy outcomes of semaglutide in the trial, showcasing the significant risk reduction in kidney events and death from cardiovascular disease. It presents insights on weight changes, kidney filtration rates, and serious adverse events, highlighting the potential benefits of the medication in high-risk populations despite concerns over rapid weight loss effects.
Drs. Karl and Spencer discuss the recent FLOW trial where semaglutide was found to be kidney protective. They also go off about the costs of these medicines and what to do (including compounding considerations).