Academic turned pharmaceutical industry head Patrick Vallance discusses his transition, ethical challenges in drug development, and initiatives for global healthcare. Topics include nitric oxide's role in cardiovascular health, personalized medicine, and researchers transitioning between academia and industry.
Transition from academia to industry for impactful drug development
Importance of collaboration, transparency, and innovation in reshaping pharmaceutical research
Deep dives
Transition from Academia to Industry in Pharmaceutical Research
Patrick Valance, a former professor who transitioned from academia to the pharmaceutical industry, reflects on his decision to join GlaxoSmithKline (GSK) as the head of research and development. This shift was motivated by his desire to have a more direct impact on human health through drug development. Valance's experience highlights the importance of bringing interdisciplinary collaboration back to industry R&D, focusing on mission-driven, human-scale teams.
Challenges and Costs in Drug Development
The podcast discusses the challenges and costs involved in drug development, emphasizing the low success rate of less than 5% for bringing new drugs to market. Valance explains the meticulous process of selecting a compound for drug development and the rigorous testing required to ensure its safety and efficacy. He touches on the substantial financial investment, often exceeding a billion dollars per medicine, needed throughout the lengthy 10-year development path.
Innovative Approaches in Drug Discovery and Openness in Clinical Trials
Valance shares insights on GSK's initiatives, such as creating a rare diseases unit and the Open Lab project in Spain, aimed at fostering collaboration in drug discovery and addressing neglected diseases. Moreover, he delves into GSK's participation in the All Trials campaign, advocating for increased transparency in clinical trial data. By embracing personalized medicine and genomic advancements, Valance envisions a future where precise targeting of treatments leads to improved success rates in drug development.
Patrick Vallance is something of a rare breed - a game-keeper turned poacher; an academic who has moved over into industry. And not just any industry, but the pharmaceutical industry. At the time, Patrick Vallance was professor of Clinical Pharmacology and head of the Department of Medicine at University College London. A pioneer of research into some of the body’s key regulatory systems, he had also been publicly critical of big Pharma for “funding studies more helpful to marketing than to advancing clinical care”. So what made him go over to "the other side"?
His involvement with the industry was limited until one evening in 2006 when he was asked a question over a dinner, a question that would be pivotal to his life and career.
Today, Patrick is head of research and development at GlaxoSmithKline, one of the world’s largest pharmaceutical companies with annual revenues in excess of £20 billion and nearly a 100,000 employees worldwide. Whilst GSK is no stranger to scandal, since he joined, Patrick has attempted to tackle the culture of secrecy that pervades the industry. He has since reshaped the way GSK carries out its research and has been behind several radical initiatives in global healthcare, to produce a more collaborative approach to tackling major diseases like malaria.
(Photo: Coloured pills)
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