The Carlat Psychiatry Podcast
Hypnotic Depression Throwback
Feb 22, 2024
Exploring the role of Z hypnotics in improving antidepressant response, differences between Zopclone mirror-image stereoisomers, comparative study in Brazil, potential antidepressant properties, and present moment awareness in depression treatment.
26:57
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Quick takeaways
- Z hypnotics may have direct antidepressant effects beyond improving sleep.
- The S isomer of Zopiclone shows pharmacokinetic advantages over the L isomer.
Deep dives
The Role of Z Hypnotics in Depression and Anxiety
Z hypnotics, such as Zopiclone and Zolpidem, have been studied for their potential to augment antidepressants in depression and anxiety disorders. These medications, acting on GABA A receptors, have shown effects similar to benzodiazepines but are primarily used for sleep. Studies suggest that Zopiclone, in particular, may have direct antidepressant and anxiolytic effects beyond improving sleep, making it a potential treatment option for depressive symptoms.
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