Oncotarget

Cholesterol-Lowering Drugs Show Promise Against Colorectal Cancer

Jul 22, 2025
Discover how cholesterol-lowering statins may play a surprising role in combating colorectal cancer. The discussion reveals exciting research showing these common drugs disrupt the Wnt/β-catenin signaling pathway, which is crucial for tumor growth. Researchers confirmed that statins not only reduce tumor growth but also do so with minimal side effects. This innovative approach could pave the way for repurposing statins in cancer therapy and prevention, offering hope against one of the leading cancer fatalities worldwide.
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INSIGHT

Statins Suppress Colorectal Cancer Growth

  • Statins, commonly used to lower cholesterol, may also suppress colorectal cancer growth by affecting key molecular pathways.
  • They disrupt Wnt/β-catenin signaling, lowering tumor-promoting proteins and encouraging cancer-suppressing behavior in cells.
INSIGHT

Statins' Molecular Impact on Tumors

  • Statins reduce colorectal tumor growth and alter tumor-related protein levels without noticeable side effects.
  • They downregulate SATB1 linked to aggressiveness and increase SATB2, which suppresses tumors, changing cancer cell behavior.
ADVICE

Repurpose Statins for Cancer Care

  • Consider repurposing statins to complement existing colorectal cancer treatments or for prevention in high-risk groups.
  • They offer a promising, cost-effective option for targeting colorectal tumor molecular machinery and reducing cancer burden.
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