#49: Cortisol Causes High Blood Sugar | DHT and Aging | PUFA, Immunosuppression, and Hibernation with Georgi Dinkov
Feb 13, 2021
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Exploring the benefits of DHT for male health, the impact of cortisol on high blood sugar, the immunosuppressive effects of PUFA, and discussions on topics like fatty acid oxidation, hibernation, and fertility optimization.
DHT can restore vitality in advanced age and improve male health.
Elevated cortisol levels contribute to insulin resistance and hyperglycemia in diabetes.
PUFA hinder energy production and lead to cell membrane disruption.
Optimal hormone levels are crucial for fertility and reproductive health.
Deep dives
DHT as a Safer Androgen than Testosterone
DHT, known as dihydrotestosterone, is gaining recognition as a safer male steroid compared to testosterone, particularly for individuals with kidney disease, prostate issues, and certain cancers. Ray Peat, a prominent figure in the discussion, has highlighted the benefits of DHT in addressing ailments and improving overall male health.
Benefits of DHT in Reversing Chronic Kidney Disease
Research suggests that DHT supplementation, along with an aromatase inhibitor, can reverse fully established stage three kidney disease by activating the androgen receptor and enhancing anti-aging genes. The activation of the androgen receptor in the kidneys plays a crucial role in reversing chronic kidney conditions.
Production of DHT and Testosterone in Men
The production of DHT in men is dependent on factors such as testosterone levels, DHEA production, and the expression of five alpha reductase protein. Men with optimal health conditions may produce up to four milligrams of DHT daily, with variations based on factors like body size and hormonal balance.
Cortisol and Gluconeogenesis in Type 2 Diabetes
Elevated cortisol levels can lead to insulin resistance and hyperglycemia in type 2 diabetes by promoting gluconeogenesis. Stress-induced cortisol release triggers a chain reaction, impacting core body temperature, muscle mass, and fat storage. Blocking cortisol synthesis or its receptor activity has shown promise in treating diabetes and related metabolic disturbances.
Effect of Pufa on Cell Structure and Energy Production
The podcast discusses how polyunsaturated fatty acids (Pufa) can impact cell structure and energy production. Pufa can disrupt cell membranes by initiating attacks on fats, leading to electron malfunction throughout the electron transport chain. Additionally, Pufa can inhibit energy production at various cellular points, affecting processes like pyruvate dehydrogenase and cytochrome C oxidase.
Impact of Fatty Acid Oxidation on Health Conditions
The episode delves into the relationship between fatty acid oxidation and various health conditions. It explores how fatty acid oxidation is linked to diseases like Huntington's disease and the role of NADH to NAD ratio in affecting metabolism pathways. The discussion highlights that fatty acid oxidation can result in the production of reactive oxygen species, which can lead to health issues.
Fertility Factors and Hormonal Influence
The podcast conversation touches on fertility concerns and the impact of hormones on reproductive health. It mentions the importance of hormones like progesterone and DHEA for enhancing fertility. Moreover, the discussion emphasizes the significance of maintaining optimal hormone levels, such as testosterone, cortisol, and prolactin, to support fertility and overall reproductive function.
