Killing and Starving Cancer Cells Using the Power of Ketogenic Diets, Metabolic Therapies, and Hyperbaric Oxygen Combined with Standard of Care with Dominic D'Agostino, Ph.D.
Apr 15, 2024
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Dr. Dominic D'Agostino discusses using ketone-based metabolic therapy and hyperbaric oxygen for cancer treatment. He explains how exercise and a low-carb diet can reduce cancer risk. They focus on metabolic therapies targeting cancer cells and improving survival rates in mice models. The podcast also covers the benefits of red light therapy, ketogenic diets in cancer treatment, and personalized integrative approaches for various types of cancer.
Therapeutic ketosis and hyperbaric oxygen can starve cancer cells through altered metabolism.
Metabolic therapies like ketogenic diets show promise for managing aggressive brain cancer cells.
Combining ketosis and oxygen therapy enhances survival rates in metastatic cancer models.
Prioritizing metabolic health through lifestyle changes can reduce cancer risk and enhance overall well-being.
Deep dives
Advancements in Ketone Metabolic Therapy for Cancer Treatment
Ketone metabolic therapy is emerging as a promising approach to enhance standard cancer care therapies like chemo, radiation, and immune-based treatments. By altering metabolic physiology through nutrition and metabolic-based therapies, such as transitioning to fatty acid and ketone metabolism, profound healing effects, especially in managing brain cancer, are being observed.
Research Journey into Cancer as a Metabolic Disease
Initial basic science research revealed distinct metabolic differences in cancer cells, particularly in mitochondrial function and reactive oxygen species production under hyperbaric oxygen conditions. Understanding the Warburg effect highlighted the unique metabolism of aggressive cancer cells, driving the exploration of ketogenic diets as a potential therapy for brain tumors.
Application of Hyperbaric Oxygen and Ketogenic Diet in Cancer Treatment
Combining therapeutic ketosis with hyperbaric oxygen therapy has shown significantly increased survival rates in metastatic cancer models. The synchronized impact of ketones and oxygen in sensitizing tumors and enhancing treatment efficacy underscores the potential of this integrated approach.
Incorporating Ketogenic Therapy, Hyperbaric Oxygen, and Exercise in Cancer Treatment
Therapeutic ketosis, hyperbaric oxygen, and exercise are identified as essential components in a comprehensive metabolic-based therapy for cancer management. Prioritizing metabolic health through biomarker optimization, maintaining glycemic control, and regular physical activity are key lifestyle strategies to reduce cancer risk and promote overall well-being.
Role of Mitochondria in Tumor Suppression
Maintaining healthy mitochondria is crucial for tumor suppression as different immunological triggers, such as certain viruses, can damage respiration and increase susceptibility to cancer. When the immune system is preoccupied with fighting infections, it may weaken, potentially leading to cancer development.
Evolution of Personal Dietary Approach
The evolution of dietary approaches, particularly regarding low carb and ketogenic diets, highlights the importance of individual experimentation. Initial experiences with a stringent four-to-one ketogenic diet led to strength and muscle loss, prompting a shift to a more sustainable low carb approach, resulting in improved cardiometabolic biomarkers.
Maintaining Ketosis for Metabolic Benefits
Sustaining a mild state of ketosis offers metabolic benefits like improved mitochondrial function and anti-inflammatory effects. Experimentation revealed that staying in ketosis effectively lowered inflammation levels, highlighting the long-term health advantages of reducing inflammatory markers and maintaining metabolic health through dietary interventions.
We’ve heard about Dr. Thomas Seyfried’s groundbreaking research and approach to cancer as a disease of metabolic dysfunction. Today’s guest was inspired by Dr. Seyfried’s metabolic approach and conducted his own research on brain cancer cells using ketone-based metabolic therapy and hyperbaric oxygen. His findings were mind-blowing!
Today on The Dhru Purohit Podcast, Dhru sits down with Dr. Dominic D’Agostino to discuss his extensive research on brain cancer cells placed in ketosis and under the pressure of hyperbaric oxygen. Dr. D’Agostino shares why his findings provide further insight into the idea that cancer cell growth can be metabolically managed. He also discusses how exercise and a low-carbohydrate diet can be used as metabolic therapies to reduce cancer risk. Dr. D’Agostino shares the critical tests we should focus on to assess our metabolic health and the essential supplements that can support ketosis.
Dr. Dominic D’Agostino is an Assistant Professor at the University of South Florida College Of Medicine, Molecular Pharmacology & Physiology, where he develops and tests metabolic therapies, including alternative energy substrates and ketogenic agents for neurological disorders, cancer, and wound healing. While studying the effects of gasses on the brains of Navy Seal divers, he developed an approach for metabolically starving cancer cells through diet and compressed oxygen, replacing chemotherapy, surgery, or radiation.
In this episode, Dhru and Dr. D’Agostino dive into (audio version / Apple Subscriber version):
The most innovative approaches to cancer (00:00:11 / 00:00:11)
The metabolic approach to cancer (1:30/1:30)
Using the hyperbaric approach in cancer patients (13:00/ 9:03)
The results of Dr. A’gostino’s studies on mice (17:00 / 13:50)
How this research translates to patients (22:00 / 18:05)
Why a ketogenic diet can be therapeutic (37:00 / 32:04)
The role of exercise in cancer prevention (53:00 / 46:35)
What lifestyle factors should we be doubling down on for prevention (55:00 / 50:14)
Dr. D’Agostino’s thoughts on a low carbohydrate diet (1:01:00 / 56:30)
The therapeutic benefits of ketosis (1:11:00 / 1:06:40)
Supplements that can support ketosis (1:19:00 / 1:12:43)
How to measure for ketosis (1:24:00 / 1:18:30)
Checking the status of your metabolic health (1:26:00 / 1:21:30)
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