Killing and Starving Cancer Cells Using the Power of Ketogenic Diets, Metabolic Therapies, and Hyperbaric Oxygen Combined with Standard of Care with Dominic D'Agostino, Ph.D.

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Apr 15, 2024

Dr. Dominic D'Agostino discusses using ketone-based metabolic therapy and hyperbaric oxygen for cancer treatment. He explains how exercise and a low-carb diet can reduce cancer risk. They focus on metabolic therapies targeting cancer cells and improving survival rates in mice models. The podcast also covers the benefits of red light therapy, ketogenic diets in cancer treatment, and personalized integrative approaches for various types of cancer.

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INSIGHT

Ketone Metabolic Therapy Rewires Brain Fuel

Ketone metabolic therapy can shift brain physiology from glucose to fat/ketone metabolism and support restorative healing.
Dominic D'Agostino links this shift to improving outcomes in brain cancer when combined with standard care.

ANECDOTE

Microscope Inside A Hyperbaric Chamber

While imaging live cells in a hyperbaric chamber, D'Agostino saw cancer mitochondria explode under high oxygen.
That unique microscope-in-chamber setup sparked his cancer metabolism research.

INSIGHT

Warburg Effect Creates Therapeutic Weakness

The Warburg effect (damaged respiration → increased glycolysis) makes many tumors highly glucose dependent.
That dependency creates a therapeutic opportunity to target cancer by limiting glucose and raising ketones.

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We’ve heard about Dr. Thomas Seyfried’s groundbreaking research and approach to cancer as a disease of metabolic dysfunction. Today’s guest was inspired by Dr. Seyfried’s metabolic approach and conducted his own research on brain cancer cells using ketone-based metabolic therapy and hyperbaric oxygen. His findings were mind-blowing!

Today on The Dhru Purohit Podcast, Dhru sits down with Dr. Dominic D’Agostino to discuss his extensive research on brain cancer cells placed in ketosis and under the pressure of hyperbaric oxygen. Dr. D’Agostino shares why his findings provide further insight into the idea that cancer cell growth can be metabolically managed. He also discusses how exercise and a low-carbohydrate diet can be used as metabolic therapies to reduce cancer risk. Dr. D’Agostino shares the critical tests we should focus on to assess our metabolic health and the essential supplements that can support ketosis.

Dr. Dominic D’Agostino is an Assistant Professor at the University of South Florida College Of Medicine, Molecular Pharmacology & Physiology, where he develops and tests metabolic therapies, including alternative energy substrates and ketogenic agents for neurological disorders, cancer, and wound healing. While studying the effects of gasses on the brains of Navy Seal divers, he developed an approach for metabolically starving cancer cells through diet and compressed oxygen, replacing chemotherapy, surgery, or radiation.

In this episode, Dhru and Dr. D’Agostino dive into (audio version / Apple Subscriber version):

The most innovative approaches to cancer (00:00:11 / 00:00:11)
The metabolic approach to cancer (1:30/1:30)
Using the hyperbaric approach in cancer patients (13:00/ 9:03)
The results of Dr. A’gostino’s studies on mice (17:00 / 13:50)
How this research translates to patients (22:00 / 18:05)
Why a ketogenic diet can be therapeutic (37:00 / 32:04)
The role of exercise in cancer prevention (53:00 / 46:35)
What lifestyle factors should we be doubling down on for prevention (55:00 / 50:14)
Dr. D’Agostino’s thoughts on a low carbohydrate diet (1:01:00 / 56:30)
The therapeutic benefits of ketosis (1:11:00 / 1:06:40)
Supplements that can support ketosis (1:19:00 / 1:12:43)
How to measure for ketosis (1:24:00 / 1:18:30)
Checking the status of your metabolic health (1:26:00 / 1:21:30)
Where to find community (1:34:00 / 1:28:16)

Also mentioned in this episode:

Keto Start
Donate to the University of Florida (Metabolic Therapy and Cancer Research #250244)
Levels

To learn more about Dr. D’Agostino, follow him on Instagram, Twitter, or his website.

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