NEJM This Week NEJM This Week — August 14, 2025
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Aug 13, 2025 Dive into discussions about the rising challenges of obesity and diabetes, and the innovative treatments for spinal muscular atrophy that promise hope for infants. Learn about a significant case involving successful lung transplantation and the implications of metabolic dysfunction in liver disease. The podcast raises alarms about the erosion of public health initiatives and the transition toward private law in healthcare, all while sharing evocative personal stories of resilience in the face of medical challenges.
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Combination Therapy Boosts Weight Loss
- The cagrillantide–semaglutide combination produced significantly greater weight loss than placebo in large Phase 3a trials across populations with and without diabetes.
- Gastrointestinal side effects were common but mostly transient and manageable with dose adjustments.
Individualize Dosing And Plan Long-Term
- Use dose adjustment and a treat-to approach to individualize obesity therapy and manage side effects.
- Extend treatment planning to lifelong maintenance rather than short-term weight loss only.
No Clear Outcome Benefit From Ringer's
- A hospital-wide policy of using lactated Ringer's instead of normal saline did not lower 90-day death or readmission rates in a cluster crossover trial.
- The trial was interrupted by COVID-19 and found no serious adverse events with either fluid strategy.