DNA damage, most often caused by oxygen free radicals, can result in mutations in proliferative cells that transform them into cancer cells. Impaired DNA repair is implicated in aging and neurodegenerative disorders. In this episode Professor Will Bohr talks about his research on the molecular mechanisms by which cells repair their nuclear and mitochondrial DNA, the involvement of impaired DNA repair in neurons in premature aging syndromes and Alzheimer’s disease, and the potential of NAD+ supplementation to sustain DNA repair and prevent neuronal degeneration.
LINKS:
Professor Bohr’s lab page: https://icmm.ku.dk/english/research-groups/bohr-group/
Review articles:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588127/pdf/cshperspectmed-AGE-a025130.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341618/pdf/nihms848291.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494058/pdf/nihms-900941.pdf
Brain Ponderings podcast with Mark Mattson