JAMA Clinical Reviews Diagnosis and Management of Cutaneous Melanoma
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Aug 25, 2025 John Kirkwood, Co-director of the Melanoma and Skin Cancer Program at the University of Pittsburgh, joins Kristin Walter to discuss cutaneous melanoma. They cover the alarming rise in incidence and highlight risk factors like UV exposure and atypical moles. Screening guidelines are clarified, stressing the need for annual exams. Kirkwood also delves into advancements in treatment, including immunotherapy, which has notably improved patient survival rates. Tune in for crucial insights into prevention and management strategies!
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Rising Melanoma Burden
- Cutaneous melanoma incidence has risen steadily for decades and is projected to keep increasing through 2040.
- By 2040 melanoma may become the second most common solid tumor in the U.S.
Flag New Or Changing Lesions
- Watch for pigmented lesions that are new, unusual, or changing as key red flags for melanoma.
- Encourage patients or family members to report changes and photograph lesions when possible for comparison.
Melanoma Subtype Distribution
- Superficial spreading melanoma is the most common subtype and accounts for about 70% of cases.
- Lentigo maligna (chronic sun damage) makes up ~15% and nodular ~5% of melanomas.