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Barbell Medicine Podcast

Episode #253: Weird Science (Gravitostat Theory)

Nov 24, 2023
10:42
Snipd AI
Explore the weird science of the gravitostat theory, which suggests increased weight can aid weight loss. Discover the role of genetics in body weight regulation and the limited effectiveness of leptin. Delve into the potential benefits of understanding hormones secreted by the bone and their impact on hunger centers in the brain.
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Podcast summary created with Snipd AI

Quick takeaways

  • The Gravitostat theory suggests that the body uses gravity to regulate body weight and fat, with specialized bone cells releasing hormones that affect hunger and satiety.
  • Genetic differences play a significant role in weight regulation between upper and lower limits, as individuals with genetics predisposing them to obesity may be more susceptible to increased calorie intake.

Deep dives

The Gravitostat Theory and Weight Regulation

The podcast discusses the Gravitostat theory, which suggests that the body uses gravity as a regulator of body weight and body fat. According to the theory, specialized cells in the bones called osteocytes sense the amount of weight being carried around. These cells release signaling hormones that affect areas of the brain involved in hunger and satiety, reducing hunger and promoting feelings of fullness. The theory posits that the bones function like an endocrine organ, releasing hormones that have an effect on the brain. This theory may provide insight into how the body establishes upper limits for weight and defends against going past those limits.

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