High Performance Health

Bitesize: Still Exhausted? Why Your Supplement Stack Isn’t Working | Dr Jacey Folkers

Aug 8, 2025
Guest
Jacey Folkers
Dr. Jacey Folkers, a practitioner specializing in the vital role of B vitamins and supplements for health, dives into the essentials of energy production. She highlights how B6, B12, and folate are crucial for red blood cell maturation, particularly for those with genetic mutations like MTHFR. The conversation also reveals caffeine's depleting effects on B vitamins and the significance of CoQ10 for energy, especially as we age. Dr. Folkers emphasizes a holistic approach to health, reminding listeners that supplements should complement, not replace, a healthy lifestyle.
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INSIGHT

B12 Blood Levels Can Be Misleading

  • High B12 blood levels do not guarantee cellular absorption or energy production.
  • B vitamins need to be in bioavailable forms like methylcobalamin, especially for those with MTHFR gene mutations.
ADVICE

Choose Bioavailable B Vitamins

  • Use methylcobalamin form of B12 and methylfolate for better absorption, especially if you have MTHFR polymorphism.
  • Maintain daily intake since B vitamins are water soluble and easily depleted by stimulants like caffeine.
INSIGHT

NAD and Glutathione in Aging

  • NAD and glutathione play critical roles in mitochondrial energy production and defense against oxidative stress.
  • Their levels decline with age, affecting energy and longevity.
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