Naturally Nourished

Episode 463: Insulin, Leptin, and Cortisol: The Triple Threat to Metabolic Success

Sep 29, 2025
Discover how insulin, leptin, and cortisol can sabotage your metabolism! Dive into the impact of insulin resistance on fat burning and how leptin influences your hunger signals. Learn about cortisol's role in cravings and fat storage, plus practical strategies for balancing these hormones. Explore the transformative power of dietary changes, like keto and fasting, and uncover insights into how these adjustments can revitalize your metabolic health. This lively discussion will equip you with knowledge to take charge of your well-being!
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INSIGHT

Insulin Often Precedes Diabetes

  • Insulin drives fat storage when chronically elevated and often precedes changes in A1C.
  • Keto and intermittent fasting rapidly improve insulin sensitivity and lower fasting insulin within days to weeks.
ADVICE

Use Keto Plus Fasting To Lower Insulin

  • Reduce carbs and use intermittent fasting to lower insulin and restore receptor sensitivity.
  • A well-formulated ketogenic diet can cut fasting insulin and HOMA scores dramatically within days.
INSIGHT

Leptin Signals Safety Not Just Fullness

  • Leptin signals long-term energy status and satiety by docking in the hypothalamus.
  • Leptin resistance causes constant hunger despite excess fat and can co-occur with insulin resistance.
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